Why it matters
The discovery that insulin could save the lives of people with type 1 diabetes (T1D) was one of the most important medical advances of the 20th century. But while today’s insulin formulations save lives, it’s difficult to achieve the tight control over blood glucose that occurs naturally in people without diabetes. This puts individuals with T1D at risk for dangerous hypoglycemic and hyperglycemic episodes.
At JDRF, we believe managing blood sugar should be much easier. We have several exciting approaches. One is designing a glucose-responsive insulin (GRI) that will circulate through the bloodstream, turning on when it’s needed to control blood sugar and turning off when blood sugar starts to go low. A successful GRI would keep tight control over blood sugar, reduce the need for glucose monitoring and probably require fewer doses to maintain control throughout the day.
We are also funding research into other medications that could dramatically improve blood-sugar management when taken along with insulin. While we work to rid the world of T1D, we are committed to eliminating or reducing wide blood-sugar fluctuations and making management of this disease better, safer and easier.