APP Study Shows Significant Improvement in Continuous Glucose Monitor Accuracy with Multiple Redundant Sensors

The development of continuous glucose monitors (CGM) has significantly advanced the treatment of T1D and spurred research efforts into combining glucose sensors and insulin pumps into artificial pancreas systems. While CGM devices alone are a valuable tool for achieving and maintaining glycemic control a higher level of accuracy and reliability will be required to achieve fully automated artificial pancreas systems.Numerous factors affect sensor accuracy. This study compared the accuracy of multiple sensors worn simultaneously (redundant sensing) with the accuracy of a single sensor in an attempt to eliminate some sources of the largest errors from a single sensor and improve the accuracy and/or reliability of blood glucose measurements.The study subjects wore four sensors during two 9-hour studies. One pair of sensors was worn on each side of the abdomen with each sensor pair placed at a predetermined distance apart and 20cm (about 8 inches) away from the opposite pair. The study showed that very large errors (a sensor reading at least 50% different from the lab-determined blood sugar value) were significantly reduced with four sensors compared with one sensor. These large errors occurred 2.6% he time with one sensor compared to 0.4% of the time with four sensors. There was also a benefit of using the average values from three or even two sensors. The group found benefit of redundancy even when sensors were positioned as close as 7mm (about one-quarter inch) together.


The Accuracy Benefit of Multiple Amperometric Glucose Sensors in People with Type 1 Diabetes, Diabetes Care Publish Ahead of Print, published online February 22, 2012.

Ramifications for Individuals with T1D:

The successful development and delivery of fully automated closed loop artificial pancreas systems to individuals with T1D will require significant improvements in CGM accuracy and reliability. Employing multiple redundant CGM sensors may be an important strategy to achieve these objectives.

JDRF Involvement:

This work was supported by grants from The Helmsley Charitable Trust, HEDCO Foundation and by the JDRF Artificial Pancreas Project.