JDRF-supported research resources
The Pancreatic ß-Cell Functional Differentiation Analysis Laboratory:
This Core laboratory at the University of Chicago provides a service to evaluate the function of candidate surrogate ß-cells (obtained from alternative sources including stem cells) and isolated human islets that may or may not have undergone various treatments. Click here for detailed information.
RNAi/Lentigenic/Transgenic Mouse Construction:
(Transgenic services are offered through the CITDH’s manipulated NOD mouse core. Germline manipulation is performed directly in NOD mice: classic transgenesis by pronuclear injection of DNA, or genomic introduction of lentiviral vectors by micro-infection, in particular for the delivery of RNAi transgenes.
Collection of transgenics and knockout mice on the NOD background:
(A collection of genetically modified NOD mice, which include gene knockouts with deficiencies in the major molecular or cellular components of the autoimmune reaction, transgenic mice with transgenes that accelerate or prevent Type-1 diabetes, and “driver” transgenic lines for islet-specific expression of regulated transgenes.