First-Ever Findings from JDRF-Funded Scientists Provide Evidence about How Killer T Cells Form Their Fatal Attraction with Beta Cells
Researchers supported by JDRF recently characterized for the first time the nature of the encounter between killer T cells and their targets—the insulin-producing beta cells in the pancreas. Using an actual T cell that was replicated or “cloned” from a patient with type 1 diabetes (T1D), the
researchers provided valuable evidence about the interaction that takes place on a molecular level and contributes to the autoimmune attack that destroys beta cells. These findings can help guide the development of targeted therapies for the prevention of T1D.