nPOD News Update

In December 2012, a study published in The Journal of the American Medical Association reported that people with type 1 diabetes (T1D) or who are at increased risk of developing the disease have smaller pancreases than people not at risk. Researchers studied pancreases from three groups of deceased donors: individuals with T1D, those with autoantibodies […]

nPOD Update

By Michelle A. Cissell, Ph.D.   In 2007, JDRF took a calculated risk by creating the Network for Pancreatic Organ Donors with Diabetes (nPOD) to collect and distribute pancreatic and other tissues from deceased organ donors with type 1 diabetes (T1D), as well as from those without the disease but with multiple antibodies indicating high […]

Letter from Leadership: Darlene C. Deecher, Ph.D.

Letter from Leadership: Darlene C. Deecher, Ph.D.

I am excited to bring this new issue of Countdown to our readers. It is an issue that speaks profoundly to the core mission of JDRF—research. At the heart of what we do is our dedication and commitment to discover, develop, and deliver advances that cure, better treat, and prevent type 1 diabetes (T1D). As we work […]

Type 1 Diabetes Investigators—Aided by JDRF Research Project—Are First to Identify “Killer” T Cells within Human Islets

Researchers recently demonstrated for the first time a direct association between human beta cell destruction and CD8 T cells, which are cells that play an important role in the body’s immune system. This autoimmune “attack” is a hallmark of T1D and it results in the destruction of insulin-producing beta cells in the pancreas. In their investigation, the researchers used human tissue samples from the pancreases of T1D organ donors obtained through nPOD, a JDRF collaborative research project. This new study provides evidence that CD8 T cells are present in the islets of the pancreas that contain beta cells. These findings are important for future research on preserving beta-cell function and establishing biomarkers for therapies for T1D.