The study is a step toward identifying small molecules that may prompt the expansion of beta cells, and it may help reveal the biological mechanisms regulating this process.
Clinical trials are showing that improvements in blood sugar control can be gained using combinations of drugs that work together to regenerate insulin-producing beta cells. Industry partnerships will be pivotal to pushing these achievements even further and bringing benefits to type 1 patients.
If these findings in mice hold true for humans, the newfound progenitor cells may represent “an obvious target for therapeutic regeneration of beta cells in diabetes,” according to the researchers.
Now that researchers have identified a protein that inhibits beta cell expansion, they can work to identify interventions that reverse this effect.