A New Switch Hitter for Type 1 Diabetes Discovered

Pancreatic cells are more adaptable and possess a greater potential for self-healing than previously assumed For decades, the prevailing wisdom was that beta cells could not regenerate and that their loss in type 1 diabetes (T1D) was irreversible—the reason why people with T1D require insulin injections for life. JDRF-funded research is helping rewrite the textbook […]

A Difficult Journey from the Lab to People with Type 1 Diabetes

New study highlights the challenges of translating promising research to effective treatments Results from a clinical study in people with type 1 diabetes (T1D) who were treated with a combination of two drugs in an attempt to improve their beta cell survival and stimulate beta cell regeneration are so far inconclusive. The study, called REPAIR-T1D […]

Potential drugs for beta cell regeneration discovered

At the April 2014 JDRF-GNF (Genomics Institute of the Novartis Research Foundation) meeting, Dr. Byran Laffitte described how GNF has the potential to identify the first disease altering therapy for T1D. He presented preclinical evidence that GNF has identified the first highly effective low molecular weight regulators of beta cell proliferation. Overall, GNF has identified […]

Discovery of New Hormone May Impact T1D

The media has come alive, exciting the type 1 diabetes (T1D) community, following the publication of findings of a new hormone in Cell on April 25. The previously unknown hormone, called betatrophin, was found in a mouse study to have the unique ability to promote the natural replication of insulin-producing beta cells. While media reports […]

New Study from JDRF-Supported Researchers Shows Stressed Beta Cells May Provoke Development of Type 1 Diabetes

JDRF-supported researchers have found that dysfunction of pancreatic beta cells precedes the onset of T1D in a mouse model of the disease. The study is the first direct demonstration that ER stress happens before the onset of T1D in an animal model. These findings help illuminate the earliest stages of T1D, and suggest that alleviating ER stress with drugs or other therapeutics might provide an avenue for slowing progression and onset of disease.

Researchers Make Old Beta Cells Act Young Again

Scientists have identified a pathway that allows beta cells to divide when they are young, but which turns off as the cells age. Finding drugs that could activate this pathway may provide a new way to make older beta cells divide again. This may be part of a strategy to maintain a quantity of beta
cells that is sufficient to restore insulin production in T1D.

New Drug Target and Potential Biomarker for Beta Cell Regeneration

An important protein involved in beta cell growth is snipped in T1D. Scientists have now identified the culprit—a molecular scissors called Bace2—and identified a chemical compound that inactivates it in mice. This inhibitor renews beta cell growth and could potentially lead to new strategies to promote beta cell regeneration to treat T1D. This is a key example of how science can advance when academic and industry scientists work together.

Sanofi-aventis and JDRF Form Partnership

JDRF and sanofi-aventis have entered into a unique partnership to develop treatments for type 1 diabetes. The focus is on people at all different stages of the disease – from those newly diagnosed to people living with it for many years – as well as on preventing diabetes in those at risk for it. Under […]