Meet the Researcher

Stephen D. Miller, Ph.D., is the Judy Gugenheim Research Professor of Microbiology–Immunology at Northwestern University Feinberg School of Medicine. Dr. Miller has spent 32 years as a faculty member at Northwestern, where his research focuses on understanding the mechanisms underlying the pathogenesis and immunoregulation of autoimmune diseases, allergic disease, and rejection of tissue and organ […]

JDRF Convenes First-Ever Encapsulation Consortium

For people living with type 1 diabetes (T1D), establishing insulin independence by implanting insulin-producing beta cells into the body would be life changing. But a challenge to this potential therapy lies in the body’s immune system, which recognizes the implanted beta cells as foreign entities or invaders and subsequently attacks them. Furthermore, the implanted beta […]

Vaccines: Tackling the root cause of type 1 diabetes

By Thania Benios In the 19th and early 20th centuries, diphtheria, measles, and mumps were frightening household names. Each year in the United States, these illnesses struck hundreds of thousands of people, and claimed up to tens of thousands of lives. Children were especially vulnerable to the bacteria and viruses that led to such staggering […]

Scientists Identify Key Differences in the Microbiome of People with Type 1 Diabetes

People with type 1 diabetes may have a different makeup of gut flora—the microbes that live in the human digestive tract—compared to that found in people without the disease. By studying the collection of genes within this microbiome and assessing their functions, researchers hope to understand if, and how, an altered microbiome contributes to autoimmunity and the onset of type 1 diabetes.

A Novel Way to Address Autoimmunity in Type 1 Diabetes

Researchers are developing a novel oral vaccine for type 1 diabetes. Using “yeast shells” to deliver proteins and other agents, the vaccine is intended to interrupt the immune attack that causes diabetes, as well as silence key genes that contribute to inflammation and autoimmunity.