Combination Therapy May Help in Islet Transplant Failure

Researchers at the University of Alberta have reported that a two-drug combination, sitagliptin and pantoprazole, can restore insulin independence in some islet transplant recipients with early signs of transplant failure. The effect was not sustained after withdrawal of the drugs; there was lack of evidence for durable effects on beta cell function or increased beta cell mass. JDRF continues to support research to improve long-term islet transplant function and to promote beta cell regeneration in all people with T1D.