First-Ever Findings from JDRF-Funded Scientists Provide Evidence about How Killer T Cells Form Their Fatal Attraction with Beta Cells

Researchers supported by JDRF recently characterized for the first time the nature of the encounter between killer T cells and their targets—the insulin-producing beta cells in the pancreas. Using an actual T cell that was replicated or “cloned” from a patient with type 1 diabetes (T1D), the
researchers provided valuable evidence about the interaction that takes place on a molecular level and contributes to the autoimmune attack that destroys beta cells. These findings can help guide the development of targeted therapies for the prevention of T1D.

Type 1 Diabetes Investigators—Aided by JDRF Research Project—Are First to Identify “Killer” T Cells within Human Islets

Researchers recently demonstrated for the first time a direct association between human beta cell destruction and CD8 T cells, which are cells that play an important role in the body’s immune system. This autoimmune “attack” is a hallmark of T1D and it results in the destruction of insulin-producing beta cells in the pancreas. In their investigation, the researchers used human tissue samples from the pancreases of T1D organ donors obtained through nPOD, a JDRF collaborative research project. This new study provides evidence that CD8 T cells are present in the islets of the pancreas that contain beta cells. These findings are important for future research on preserving beta-cell function and establishing biomarkers for therapies for T1D.

All the Right Moves: Support for a military child with newly diagnosed type 1 diabetes

All the Right Moves: Support for a military child with newly diagnosed type 1 diabetes

My nine-year-old daughter was diagnosed with type 1 diabetes (T1D) five days ago. We are a military family currently stationed in South Korea. We are with very few English resources in the area. It looks like we will get an emergency move to our next duty station in El Paso, TX, in a couple of weeks. How do we find quality care in a foreign country, manage an international move with a child with T1D, and find quality care to deal with a new diagnosis?

Letter from Leadership: Mania Boyder

Letter from Leadership: Mania Boyder

Season’s greetings to all! Our December issue of Countdown, JDRF’s leading publication, brings you an abundance of research and advocacy news, and photos from some of our most recent events from coast to coast and across the globe. You’ll read about how JDRF is making great strides in better treatments, prevention, and a cure for […]

JDRF-Helmsley Charitable Trust Collaboration

JDRF and the Leona M. and Harry B. Helmsley Charitable Trust, two of the largest non-government funders of type 1 diabetes (T1D) programs, teamed up in November to optimize their common efforts to improve the health of people living with the disease. Since 2007, the Leona M. and Harry B. Helmsley Charitable Trust has provided […]

Letter from Leadership: Mary Tyler Moore

Letter from Leadership: Mary Tyler Moore

This year marks JDRF’s seventh Children’s Congress. I find it inspiring that the very idea for Children’s Congress came from a child with type 1 diabetes. In 1999, eight-year-old Tommy Solo of Massachusetts heard his mother talking to a group of adults about going to Washington, D.C., to petition Congress for more funding for type […]

JDRF Heroes and Corporate Partners

The success of the JDRF Children’s Congress is significantly strengthened by a unique collaboration between JDRF advocates, government representatives, and corporate sponsors who combine their resources and their voices to keep type 1 diabetes research moving forward. At the Corporate Partner Recognition Luncheon on June 21, JDRF leadership and delegates recognized two 2011 Children’s Congress […]

Friendraiser Contest Winners

This past April, more than two months before they would make their voices heard in Washington, D.C., as delegates of JDRF’s 2011 Children’s Congress, 89 families were already warming up those voices. From April 1 to 30, the Friendraiser Campaign challenged delegates to educate their extended networks of family and friends about type 1 diabetes […]

Letter from Leadership

Letter from Leadership

  Welcome to Countdown! For all of us connected to type 1 diabetes—adults and children and their families, physicians, researchers, everyone at JDRF—we are living in exciting times! In the past eight years that I have been at JDRF, I have seen significant advances in type 1 diabetes discovery research and its clinical translation, and […]