A Well-Known Hormone Turns On Beta Cell Survival Genes

A hormone called GLP-1 has long been thought to have a positive impact on beta cell survival, and now scientists have started to uncover how it works. The new findings provide scientists with insights to improve the effects of currently available drugs that may prevent beta cell loss and promote beta cell survival in people with T1D or in those in the transplant setting.

Researchers Make Old Beta Cells Act Young Again

Scientists have identified a pathway that allows beta cells to divide when they are young, but which turns off as the cells age. Finding drugs that could activate this pathway may provide a new way to make older beta cells divide again. This may be part of a strategy to maintain a quantity of beta
cells that is sufficient to restore insulin production in T1D.

New Drug Target and Potential Biomarker for Beta Cell Regeneration

An important protein involved in beta cell growth is snipped in T1D. Scientists have now identified the culprit—a molecular scissors called Bace2—and identified a chemical compound that inactivates it in mice. This inhibitor renews beta cell growth and could potentially lead to new strategies to promote beta cell regeneration to treat T1D. This is a key example of how science can advance when academic and industry scientists work together.

Vaccines: Tackling the root cause of type 1 diabetes

By Thania Benios In the 19th and early 20th centuries, diphtheria, measles, and mumps were frightening household names. Each year in the United States, these illnesses struck hundreds of thousands of people, and claimed up to tens of thousands of lives. Children were especially vulnerable to the bacteria and viruses that led to such staggering […]

Scientists Identify Key Differences in the Microbiome of People with Type 1 Diabetes

People with type 1 diabetes may have a different makeup of gut flora—the microbes that live in the human digestive tract—compared to that found in people without the disease. By studying the collection of genes within this microbiome and assessing their functions, researchers hope to understand if, and how, an altered microbiome contributes to autoimmunity and the onset of type 1 diabetes.